INHIBITION OF THE GLYCOLYTIC-ENZYMES IN THE TRYPANOSOME - AN APPROACH IN THE DEVELOPMENT OF NEW LEADS IN THE THERAPY OF PARASITIC DISEASES

被引：29

作者：

PERIE, J ^{[1
]}

RIVIEREALRIC, I ^{[1
]}

BLONSKI, C ^{[1
]}

GEFFLAUT, T ^{[1
]}

DEVIGUERIE, NL ^{[1
]}

TRINQUIER, M ^{[1
]}

WILLSON, M ^{[1
]}

OPPERDOES, FR ^{[1
]}

CALLENS, M ^{[1
]}

机构：

[1] INT INST CELLULAR & MOLEC PATHOL,TROP DIS RES UNIT,B-1200 BRUSSELS,BELGIUM

来源：

PHARMACOLOGY & THERAPEUTICS | 1993年 / 60卷 / 02期

关键词：

GLYCOLYTIC ENZYMES; INHIBITION; SUICIDE INHIBITORS; ALLOSTERIC INHIBITORS; ALDOLASE; TRYPANOSOMA BRUCEI;

D O I：

10.1016/0163-7258(93)90016-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glycolysis in the trypanosome represents an important target for the development of new therapeutic agents due to the fact that this metabolism is essential for the parasite, glucose being its sole source of energy. In addition, different features of this metabolism and those associated with glycolytic enzymes offer opportunities for the development of efficient and selective compounds. Examples are given in this work of inhibitors directed to the enzymes aldolase and glyceraldehyde-phosphate-dehydrogenase and also of molecules acting specifically on the clusters of basic amino-acids present at the surfaces of the glycolytic enzymes in the parasite.

引用

页码：347 / 365

页数：19

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