CU-ZN SUPEROXIDE-DISMUTASE ACTIVITIES IN PLATELETS FROM STABLE BRONCHIAL ASTHMATIC-PATIENTS

被引：14

作者：

KUROSAWA, M ^{[1
]}

KOBAYASHI, H ^{[1
]}

NAKANO, M ^{[1
]}

机构：

[1] HAMAMATSU UNIV SCH MED, PHOTON MED RES CTR, HAMAMATSU, SHIZUOKA 43131, JAPAN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1993年 / 101卷 / 01期

关键词：

SUPEROXIDE DISMUTASE; PLATELET; BRONCHIAL ASTHMA; ASPIRIN-SENSITIVE ASTHMA;

D O I：

10.1159/000236499

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Cu-Zn superoxide dismutase (SOD) activities in platelets from stable bronchial asthmatic patients were measured using 2-methyl-6-[p-methoxyphe-nyl]3,7-dihydroimidazo[1,2-a]pyrazin-3-one as a chemiluminescence probe. Cu-Zn SOD activities in platelets from the asthmatics were significantly higher than those from normal healthy subjects. Platelet Cu-Zn SOD activities were significantly higher in atopic than in non-atopic asthmatics. There were no significant differences in platelet Cu-Zn SOD activities between aspirin-sensitive and aspirin-tolerant patients. These results suggest that an oxidant-to-antioxidant imbalance may play a role in the inflammatory situations in the airways of asthmatics.

引用

页码：61 / 65

页数：5

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