DISSOLUTION RATE STUDY OF FRESH AND AGING TRIAMTERENE-UREA SOLID DISPERSIONS

Triamterene-urea solid dispersions of varying weight fractions were elaborated by the melting carrier method and their dissolution profiles compared with the pure drug and physical mixtures. The dissolution rates of triamterene from solid dispersions were faster than the pure drug and physical mixtures. Solubility studies revealed a linear increase in the solubility of the triamterene with the increase of urea concentration. The intrinsic dissolution rates, determined by the rotating disc method, showed linear dissolution profiles in spite of that the scanning electron microscopy examination revealed that the surfaces do not maintain constant during the dissolution process. Aging of the different preparations for one year at room temperature does not induced significant changes in their dissolution profiles.