SELECTIVE AND SENSITIVE ONLINE FLOW EXTRACTION, PRECONCENTRATION AND NORMAL-PHASE LIQUID-CHROMATOGRAPHY

被引：10

作者：

HALVAX, JJ

WIESE, G

VANBENNEKOM, WP

BULT, A

机构：

[1] Department of Pharmaceutical Analysis, Utrecht University, 3511 GH Utrecht

来源：

ANALYTICA CHIMICA ACTA | 1990年 / 239卷 / 02期

关键词：

Beverages; Caffeine; Extraction; Food; Urine; Zidovudine;

D O I：

10.1016/S0003-2670(00)83850-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The on-line coupling of flow extraction with normal-phase liquid chromatography (LC) was studied. The aqueous sample was introduced into the extraction unit and the organic phase of this unit was fed to the LC system, via a precolumn. This column preconcentrated the sample, thereby diminishing band broadening and improving the sensitivity. Caffeine and zidovudine were used as test compounds; the limits of detection in standard solutions were 2 × 10-9 and 1.2 × 10-8 M, respectively. The applicability of the method to real samples (beverages and urine) was investigated. The correlation coefficient of the calibration graphs was ≥ 0.99. © 1990.

引用

页码：171 / 179

页数：9

共 14 条

[1] DISPERSION IN PHASE SEPARATORS FOR FLOW-INJECTION EXTRACTION SYSTEMS [J].