INFECTION OF DONOR LYMPHOCYTES WITH HUMAN T-LYMPHOTROPHIC VIRUS TYPE-1 (HTLV-I) FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR HTLV-I POSITIVE ADULT T-CELL LEUKEMIA

被引：41

作者：

LJUNGMAN, P

LAWLER, M

ASJO, B

BOGDANOVIC, G

KARLSSON, K

MALM, C

MCCANN, SR

RINGDEN, O

GAHRTON, G

机构：

[1] HUDDINGE UNIV HOSP,DEPT CLIN IMMUNOL,S-14186 HUDDINGE,SWEDEN

[2] HUDDINGE UNIV HOSP,DEPT TRANSPLANTAT SURG,S-14186 HUDDINGE,SWEDEN

[3] KAROLINSKA INST,HUDDINGE,SWEDEN

[4] LINKOPING UNIV HOSP,DEPT HAEMATOL,S-58185 LINKOPING,SWEDEN

[5] SWEDISH INST INFECT DIS CONTROL,DEPT VIROL,STOCKHOLM,SWEDEN

[6] UNIV BERGEN,DEPT MICROBIOL & IMMUNOL,BERGEN,NORWAY

[7] UNIV DUBLIN TRINITY COLL,DEPT GENET,DUBLIN 2,IRELAND

[8] ST JAMES HOSP,DEPT CLIN HAEMATOL & ONCOL,DUBLIN 8,IRELAND

[9] UNIV DUBLIN TRINITY COLL,DUBLIN 2,IRELAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 88卷 / 02期

关键词：

HTLV-1; ADULT T-CELL LEUKEMIA; BMT; PCR; RELAPSE;

D O I：

10.1111/j.1365-2141.1994.tb05040.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human T lymphotrophic virus type 1 (HTLV-I) associated leukaemia has a poor prognosis even with chemotherapy. We describe a patient with adult T-cell leukaemia treated with allogeneic bone marrow transplantation from an HTLV-I negative identical sibling donor. During follow-up after bone marrow transplantation, HTLV-I could be repeatedly isolated inspite of anti-viral prophylaxis. The patient died of an acute encephalitis and HTLV-I could be detected in autopsy material from the brain. By a PCR-based technique using short tandem repeats (STRs) it was shown that the patient's haemopoiesis was of donor origin. This shows the infection of donor cells in vivo by an aetiological agent which has been implicated in the leukaemogenic process for adult T-cell leukaemia.

引用

页码：403 / 405

页数：3

共 12 条

[1] RECIPIENT ORIGIN OF BONE MARROW-DERIVED FIBROBLASTIC STROMAL CELLS DURING ALL PERIODS FOLLOWING BONE-MARROW TRANSPLANTATION IN HUMANS [J].