BIFUNCTIONAL INVOLVEMENT OF THE HYDROXYNAPHTHOATE ESTER MOIETY IN THE ACTIVATION OF NEOCARZINOSTATIN CHROMOPHORE IN DNA-MEDIATED SITE-SPECIFIC CLEAVAGE

被引:36
作者
HENSENS, OD [1 ]
HELMS, GL [1 ]
ZINK, DL [1 ]
CHIN, DH [1 ]
KAPPEN, LS [1 ]
GOLDBERG, IH [1 ]
机构
[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
关键词
D O I
10.1021/ja00076a087
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:11030 / 11031
页数:2
相关论文
共 12 条
[1]   NEOCARZINOSTATIN - CHEMICAL CHARACTERIZATION AND PARTIAL STRUCTURE OF THE NON-PROTEIN CHROMOPHORE [J].
ALBERSSCHONBERG, G ;
DEWEY, RS ;
HENSENS, OD ;
LIESCH, JM ;
NAPIER, MA ;
GOLDBERG, IH .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 95 (03) :1351-1356
[2]  
BECKWITH ALJ, 1980, REARRANGEMENTS GROUN, V1, P209
[3]   MECHANISM OF NEOCARZINOSTATIN ACTION - ROLE OF DNA MICROSTRUCTURE IN DETERMINATION OF CHEMISTRY OF BISTRANDED OXIDATIVE DAMAGE [J].
GOLDBERG, IH .
ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (07) :191-198
[4]   MECHANISM OF ACTIVATION OF THE ANTITUMOR ANTIBIOTIC NEOCARZINOSTATIN BY MERCAPTAN AND SODIUM-BOROHYDRIDE [J].
HENSENS, OD ;
GOLDBERG, IH .
JOURNAL OF ANTIBIOTICS, 1989, 42 (05) :761-768
[5]   NEOCARZINOSTATIN CHROMOPHORE - PRESENCE OF A HIGHLY STRAINED ETHER RING AND ITS REACTION WITH MERCAPTAN AND SODIUM-BOROHYDRIDE [J].
HENSENS, OD ;
DEWEY, RS ;
LIESCH, JM ;
NAPIER, MA ;
REAMER, RA ;
SMITH, JL ;
ALBERSSCHONBERG, G ;
GOLDBERG, IH .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 113 (02) :538-547
[6]   DNA CONFORMATION INDUCED ACTIVATION OF AN ENEDIYNE FOR SITE-SPECIFIC CLEAVAGE [J].
KAPPEN, LS ;
GOLDBERG, IH .
SCIENCE, 1993, 261 (5126) :1319-1321
[7]   SYNTHESIS VIA VINYL SULFONES .45. INTRAMOLECULAR OXYGEN VERSUS CARBON ALKYLATION OF NAPHTHOATE ESTERS - A CAVEAT ON THE MECHANISTIC ASPECTS OF NEOCARZINOSTATIN CHEMISTRY [J].
LAMOTHE, M ;
FUCHS, PL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (11) :4483-4496
[9]   EVIDENCE FOR SPONTANEOUS, LOW-TEMPERATURE BIRADICAL FORMATION FROM A HIGHLY REACTIVE NEOCARZINOSTATIN CHROMOPHORE THIOL CONJUGATE [J].
MYERS, AG ;
PROTEAU, PJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (03) :1146-1147
[10]   STEREOCHEMICAL ASSIGNMENT OF NEOCARZINOSTATIN CHROMOPHORE - STRUCTURES OF NEOCARZINOSTATIN CHROMOPHORE METHYL THIOGLYCOLATE ADDUCTS [J].
MYERS, AG ;
PROTEAU, PJ ;
HANDEL, TM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (21) :7212-7214