NEW CHIRAL BLOCKS FOR INTRODUCING THE SIDE-CHAIN OF HMG-COA REDUCTASE INHIBITORS

被引:25
作者
URABE, H [1 ]
MATSUKA, T [1 ]
SATO, F [1 ]
机构
[1] TOKYO INST TECHNOL,DEPT BIOMOLEC ENGN,TOKYO 152,JAPAN
关键词
D O I
10.1016/S0040-4039(00)74684-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A couple of versatile building blocks (8 and 9) of the side chain portion found in many HMG-CoA reductase inhibitors have been prepared. The successful introduction of the side chain to an aromatic ring by 8 or 9 has been demonstrated.
引用
收藏
页码:4183 / 4186
页数:4
相关论文
共 18 条
[1]   SYNTHESIS OF A NOVEL HMG-COA REDUCTASE INHIBITOR [J].
BAADER, E ;
BARTMANN, W ;
BECK, G ;
BERGMANN, A ;
JENDRALLA, H ;
KESSELER, K ;
WESS, G ;
SCHUBERT, W ;
GRANZER, E ;
VONKEREKJARTO, B ;
KRAUSE, R .
TETRAHEDRON LETTERS, 1988, 29 (08) :929-930
[2]  
Chem K.-M., 1987, CHEM LETT
[3]   A SIMPLE SYNTHESIS OF PRIMARY E-ALLYLIC AMINES FROM 1-TRIBUTYLSTANNYL-3-BIS(TRIMETHYLSILYL)AMINO PROP-1-ENE [J].
CORRIU, RJP ;
BOLIN, G ;
MOREAU, JJE .
TETRAHEDRON LETTERS, 1991, 32 (33) :4121-4124
[4]   DIASTEREOSELECTION IN THE ADDITION OF ENOLATES TO CHIRAL ALPHA,BETA-EPOXYALDEHYDES [J].
ESCUDIER, JM ;
BALTAS, M ;
GORRICHON, L .
TETRAHEDRON LETTERS, 1991, 32 (39) :5345-5348
[5]  
HUDRLIK PF, 1975, J ORG CHEM, V40, P2264
[6]   SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NEW HMG-COA REDUCTASE INHIBITORS .2. DERIVATIVES OF 7-(1H-PYRROL-3-YL)-SUBSTITUTED-3,5-DIHYDROXYHEPT-6(E)-ENOIC (-HEPTANOIC) ACIDS [J].
JENDRALLA, H ;
BAADER, E ;
BARTMANN, W ;
BECK, G ;
BERGMANN, A ;
GRANZER, E ;
VONKEREKJARTO, B ;
KESSELER, K ;
KRAUSE, R ;
SCHUBERT, W ;
WESS, G .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) :61-70
[7]   ASYMMETRIC-SYNTHESIS VIA ACETAL TEMPLATES .15. THE PREPARATION OF ENANTIOMERICALLY PURE MEVINOLIN ANALOGS [J].
JOHNSON, WS ;
KELSON, AB ;
ELLIOTT, JD .
TETRAHEDRON LETTERS, 1988, 29 (31) :3757-3760
[8]   HIGHLY STEREOCONTROLLED, MULTIGRAM SCALE SYNTHESIS OF LEUKOTRIENE-B4 [J].
KOBAYASHI, Y ;
SHIMAZAKI, T ;
SATO, F .
TETRAHEDRON LETTERS, 1987, 28 (47) :5849-5852
[9]   A HIGHLY STEREOSELECTIVE ROUTE TO THE 4 STEREOISOMERS OF A 6-CARBON SYNTHON [J].
PRASAD, K ;
CHEN, KM ;
REPIC, O ;
HARDTMANN, GE .
TETRAHEDRON-ASYMMETRY, 1990, 1 (05) :307-310
[10]   3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A REDUCTASE INHIBITORS .6. TRANS-6-[2-(SUBSTITUTED-1-NAPHTHYL)ETHYL(OR -ETHENYL)]-3,4,5,6-TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONES [J].
PRUGH, JD ;
ALBERTS, AW ;
DEANA, AA ;
GILFILLIAN, JL ;
HUFF, JW ;
SMITH, RL ;
WIGGINS, JM .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (02) :758-765