MECHANISM OF ACTION OF HYPOGLYCEMIA-PRODUCING BIGUANIDES - RE-EVALUATION AND A MOLECULAR THEORY

被引：83

作者：

SCHAFER, G ^{[1
]}

机构：

[1] MED HSCH HANOVER, DEPT BIOCHEM, HANOVER, FED REP GER

来源：

BIOCHEMICAL PHARMACOLOGY | 1976年 / 25卷 / 18期

关键词：

D O I：

10.1016/0006-2952(76)90423-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The targets for biguanide action are biological membranes in a rather unspecific manner. From their molecular mechanism of interaction with membranes a large multiplicity of possible consequences is self-evident, which does not necessarily imply that biguanides or related compounds have to possess blood sugar lowering activity. The hypoglycemic effect appears as an accident rather than as a principle of drug action. This agrees with the fact that only a few compounds among biguanides are useful blood sugar lowering agents; pronounced species differences exist, and many biguanides are without effects on blood sugar. The side-effects of higher concentrations of biguanide and toxicity may equally well be explained on the basis of their membrane-modifying capability. Rat liver mitochondria were studied.

引用

页码：2005 / 2014

页数：10

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