DOES TRANS-LESION SYNTHESIS EXPLAIN THE UV-RADIATION RESISTANCE OF DNA-SYNTHESIS IN C-ELEGANS EMBRYOS

被引：13

作者：

HARTMAN, P

REDDY, J

SVENDSEN, BA

机构：

[1] Department of Biology, Texas Christian University, Fort Worth

来源：

MUTATION RESEARCH | 1991年 / 255卷 / 02期

关键词：

CAENORHABDITIS-ELEGANS; NEMATODE; DNA SYNTHESIS; TRANS-LESION SYNTHESIS;

D O I：

10.1016/0921-8777(91)90050-Y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Over 10-fold larger fluences were required to inhibit both DNA synthesis and cell division in wild-type C elegans embryos as compared with other model systems or C elegans rad mutants. In addition, unlike in other organisms, the molecular weight of daughter DNA strands was reduced only after large, superlethal fluences. The molecular weight of nascent DNA fragments exceeded the interdimer distance by up to 19-fold, indicating that C elegans embryos can replicate through non-instructional lesions. This putative trans-lesion synthetic capability may explain the refractory nature of UV radiation on embryonic DNA synthesis and nuclear division in C elegans.

引用

页码：163 / 173

页数：11

共 40 条

[1] ABNORMAL RECOVERY OF DNA-REPLICATION IN ULTRAVIOLET-IRRADIATED CELL-CULTURES OF DROSOPHILA-MELANOGASTER WHICH ARE DEFECTIVE IN DNA-REPAIR [J].