PHARMACOKINETIC ASPECTS OF CAFFEINE IN PREMATURE-INFANTS

被引:12
作者
DECAROLIS, MP
ROMAGNOLI, C
MUZII, U
TORTOROLO, G
CHIAROTTI, M
DEGIOVANNI, N
CARNEVALE, A
机构
[1] UNIV CATTOLICA SACRO CUORE, INST FORENS MED, I-00168 ROME, ITALY
[2] UNIV CHIETI, INST FORENS MED, CHIETI, ITALY
来源
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS | 1991年 / 16卷 / 03期
关键词
CAFFEINE; THEOPHYLLINE; DRUG METABOLISM; APNEA; PREMATURE INFANTS;
D O I
10.1159/000480570
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The pharmacokinetic profile of caffeine was studied in 15 premature infants. Five infants received a single intravenous dose of 10 mg/kg of caffeine citrate 100% at birth and on the 15th day of life. Ten neonates were studied during daily therapy with caffeine for prophylaxis of idiopathic apnea. The time course of plasma and urinary concentrations of caffeine and theophylline shows that caffeine is transformed to theophylline at birth, while total urinary xanthines decrease significantly (p < 0.001) 72 h after the loading dose given on the 15th day of life. During the whole period of treatment, the decrease in total urinary xanthines and the constant urinary percentage elimination of theophylline are due to further metabolism of theophylline. We confirm that the intravenous loading dose of 10 mg/kg can rapidly obtain therapeutic blood levels of caffeine. We also confirm that the maintenance therapy can be carried out with a single daily dose.
引用
收藏
页码:117 / 122
页数:6
相关论文
共 14 条
[1]  
ALBRIDGE A, 1979, CLIN PHARMACOL THER, V25, P447
[2]   MATURATION OF CAFFEINE ELIMINATION IN INFANCY [J].
ARANDA, JV ;
COLLINGE, JM ;
ZINMAN, R ;
WATTERS, G .
ARCHIVES OF DISEASE IN CHILDHOOD, 1979, 54 (12) :946-949
[3]   PHARMACOKINETIC PROFILE OF CAFFEINE IN THE PREMATURE NEWBORN-INFANT WITH APNEA [J].
ARANDA, JV ;
COOK, CE ;
GORMAN, W ;
COLLINGE, JM ;
LOUGHNAN, PM ;
OUTERBRIDGE, EW ;
ALDRIDGE, A ;
NEIMS, AH .
JOURNAL OF PEDIATRICS, 1979, 94 (04) :663-668
[4]   EFFICACY OF CAFFEINE IN TREATMENT OF APNEA IN LOW-BIRTH-WEIGHT INFANT [J].
ARANDA, JV ;
GORMAN, W ;
BERGSTEINSSON, H ;
GUNN, T .
JOURNAL OF PEDIATRICS, 1977, 90 (03) :467-472
[5]  
ARANDA JV, 1981, PEDIATR CLIN N AM, V28, P113
[6]   HEPATIC MICROSOMAL DRUG OXIDATION AND ELECTRON-TRANSPORT IN NEWBORN-INFANTS [J].
ARANDA, JV ;
MACLEOD, SM ;
RENTON, KW ;
EADE, NR .
JOURNAL OF PEDIATRICS, 1974, 85 (04) :534-542
[7]   METABOLISM OF THEOPHYLLINE TO CAFFEINE IN PREMATURE NEWBORN-INFANTS [J].
BORY, C ;
BALTASSAT, P ;
PORTHAULT, M ;
BETHENOD, M ;
FREDERICH, A ;
ARANDA, JV .
JOURNAL OF PEDIATRICS, 1979, 94 (06) :988-993
[8]   CAFFEINE, A METABOLITE OF THEOPHYLLINE DURING THE TREATMENT OF APNEA IN THE PREMATURE-INFANT [J].
BOUTROY, MJ ;
VERT, P ;
ROYER, RJ ;
MONIN, P ;
ROYERMORROT, MJ .
JOURNAL OF PEDIATRICS, 1979, 94 (06) :996-998
[9]   PHYSIOLOGICAL DISPOSITION OF CAFFEINE [J].
BURG, AW .
DRUG METABOLISM REVIEWS, 1975, 4 (02) :199-228
[10]   URINARY METABOLITES OF CAFFEINE IN THE PREMATURE-INFANT [J].
GORODISCHER, R ;
ZMORA, E ;
BENZVI, Z ;
WARSZWASKI, D ;
YAARI, A ;
SOFER, S ;
ARNAUD, MJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 31 (04) :497-499