ELECTRONIC INTERACTIONS WITHIN THE MOLECULES OF (1-AZIRIDINYL)CYCLOPHOSPHAZENES WITH AROMATIC SUBSTITUENTS

The synthesis and spectral characteristics of the new series of cytostatically active ortho- (dioxy-or diaminoarylene) substituted (1-aziridinyl) cyclophosphazenes of general formula N3P3Az4R2, where 2R = o-phenylenediamino, 1,1-dioxybinaphthylo-2,2', and 2,2'-dioxybinaphthylo-1,1', are described. UV and H-1 NMR spectroscopies have provided evidence for the intramolecular electronic interactions between the aromatic pi-electron systems and the lone electron pairs of the 1-aziridinyl groups attached to the same phosphazene rings. The existence of strong hydrogen bonding in the molecules of phenyl(endi)amino (1-aziridinyl)cyclophosphazenes is revealed by IR spectral data. The recognized intramolecular interactions may be of importance for elucidating the superior cytostatic activity in the studied series of compounds.