EVIDENCE FOR THE PARTICIPATION OF ENDOGENOUS ACTIVIN-A ERYTHROID-DIFFERENTIATION FACTOR IN THE REGULATION OF ERYTHROPOIESIS

被引：95

作者：

SHIOZAKI, M ^{[1
]}

SAKAI, R ^{[1
]}

TABUCHI, M ^{[1
]}

NAKAMURA, T ^{[1
]}

SUGINO, K ^{[1
]}

SUGINO, H ^{[1
]}

ETO, Y ^{[1
]}

机构：

[1] INST PHYS & CHEM RES,FRONTIER RES PROGRAM,WAKO,SAITAMA 35101,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 05期

关键词：

FOLLICLE-STIMULATING HORMONE-RELEASING PROTEIN; INHIBIN; BURST-PROMOTING ACTIVITY; HEMATOPOIESIS; FOLLISTATIN;

D O I：

10.1073/pnas.89.5.1553

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Activin A/erythroid differentiation factor (EDF) is a human protein that induces differentiation of a murine erythroleukemia cell (the Friend cell). In this study, we demonstrate that endogenous activin A/EDF activity is present in murine bone marrow and spleen. In addition, this activity is secreted by bone marrow and spleen cells in primary culture. Administration of follistatin (a specific binding protein for activin A/EDF) to mice results in a decrease of erythroid progenitors in the bone marrow and spleen. These findings support the concept that activin A/EDF and follistatin have opposing actions in the regulation of erythropoiesis.

引用

页码：1553 / 1556

页数：4

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