MYASTHENOGENICITY OF A HUMAN ACETYLCHOLINE-RECEPTOR ALPHA-SUBUNIT PEPTIDE - MORPHOLOGY AND IMMUNOLOGY

被引：8

作者：

MATSUO, H

TSUJIHATA, M

SATOH, A

TAKEO, G

YOSHIMURA, T

NAGATAKI, S

机构：

[1] NAGASAKI UNIV, SCH MED, DEPT INTERNAL MED 1, 7-1 SAKAMOTO MACHI, NAGASAKI 852, JAPAN

[2] NAGASAKI UNIV, SCH ALLIED MED SCI, NAGASAKI 852, JAPAN

来源：

MUSCLE & NERVE | 1992年 / 15卷 / 03期

关键词：

PEPTIDE SYNTHETIC; AUTOIMMUNE MYASTHENIA GRAVIS; EXPERIMENTAL ACETYLCHOLINE RECEPTOR; ANTIGENIC DETERMINANT; SYNTHETIC; MYASTHENOGENICITY;

D O I：

10.1002/mus.880150305

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Each of 10 rats inoculated with a synthetic peptide comprising residues 125-147 (without a disulfide bond) of human acetylcholine receptor (AChR) alpha-subunit (H-alpha) had deposits of IgG and C3 (immune complexes) and showed morphological changes in the fine structure at the motor end-plates 5 weeks after a single immunization. Antibody to the H-alpha peptides was elevated 1 week after immunization, but, antibody levels to solubilized human or rat AChR were very low in 8 of the 1 0 rats. These results suggest that the immune response to peptide H-alpha is the myasthenogenic site, which induces morphological change at the end-plates.

引用

收藏

页码：282 / 287

页数：6

相关论文

共 26 条

[1] MYASTHENIC ANTIBODIES CROSS-LINK ACETYLCHOLINE RECEPTORS TO ACCELERATE DEGRADATION [J].

DRACHMAN, DB ;

ANGUS, CW ;

ADAMS, RN ;

MICHELSON, JD ;

HOFFMAN, GJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1978, 298 (20) :1116-1122

[2]

ENGEL AG, 1977, MAYO CLIN PROC, V52, P267

[3] HISTOMETRIC ANALYSIS OF ULTRASTRUCTURE OF NEUROMUSCULAR JUNCTION IN MYASTHENIA GRAVIS AND IN MYASTHENIC SYNDROME [J].

ENGEL, AG ;

SANTA, T .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1971, 183 (NSEP) :46-+

[4] MOTOR END PLATE IN MYASTHENIA-GRAVIS AND IN EXPERIMENTAL AUTOIMMUNE MYASTHENIA-GRAVIS - QUANTITATIVE ULTRASTRUCTURAL-STUDY [J].

ENGEL, AG ;

TSUJIHATA, M ;

LINDSTROM, JM ;

LENNON, VA .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1976, 274 (MAY28) :60-79

[5]

FRAKER PJ, 1978, BIOCHEM BIOPH RES CO, V80, P849, DOI 10.1016/0006-291X(78)91322-0

[6] SYNTHETIC PEPTIDES AND THEIR ANTIBODIES IN THE ANALYSIS OF THE ACETYLCHOLINE-RECEPTOR [J].

FUCHS, S ;

NEUMANN, D ;

SAFRAN, A ;

SOUROUJON, M ;

BARCHAN, D ;

FRIDKIN, M ;

GERSHONI, JM ;

MANTEGAZZA, R ;

PIZZIGHELLA, S .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 505 :256-271

[7] A JUXTA-MEMBRANE EPITOPE ON THE HUMAN ACETYLCHOLINE-RECEPTOR RECOGNIZED BY T-CELLS IN MYASTHENIA-GRAVIS [J].

HARCOURT, GC ;

SOMMER, N ;

ROTHBARD, J ;

WILLCOX, HNA ;

NEWSOMDAVIS, J .

JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (04) :1295-1300

[8]

HEINRIKSON RL, 1984, ANAL BIOCHEM, V136, P65, DOI 10.1016/0003-2697(84)90307-5

[9]

Lennon V A, 1988, Ann N Y Acad Sci, V540, P516, DOI 10.1111/j.1749-6632.1988.tb27156.x

[10] REGION OF PEPTIDE 125-147 OF ACETYLCHOLINE RECEPTOR-ALPHA SUBUNIT IS EXPOSED AT NEUROMUSCULAR-JUNCTION AND INDUCES EXPERIMENTAL AUTOIMMUNE MYASTHENIA-GRAVIS, T-CELL IMMUNITY, AND MODULATING AUTOANTIBODIES [J].

LENNON, VA ;

MCCORMICK, DJ ;

LAMBERT, EH ;

GRIESMANN, GE ;

ATASSI, MZ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8805-8809