(PLUS-OR-MINUS)11-AMINO-2,6-DIMETHYL-1,2,3,4-TETRAHYDRO-6H-QUININDOLIN-1-ONE, A NOVEL GABA(A) MODULATOR WITH POTENTIAL ANXIOLYTIC ACTIVITY

被引：9

作者：

BLACKBURN, TP ^{[1
]}

BOLTON, D ^{[1
]}

FORBES, IT ^{[1
]}

JOHNSON, CN ^{[1
]}

MARTIN, RT ^{[1
]}

THOMAS, DR ^{[1
]}

THOMPSON, M ^{[1
]}

UPTON, N ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80129-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ketone isosteres have been investigated in a series of pyrido[2,3-b]indoles (alpha-carbolines). The incorporation of ring fusion into alpha-carbolines to produce the rigid quinindoline nucleus provides a GABA(A) modulator with both increased potency and a longer duration of action.

引用

页码：279 / 284

页数：6

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