A LOW-MOLECULAR-WEIGHT FUCOIDAN FRACTION FROM THE BROWN SEAWEED PELVETIA-CANALICULATA

被引：71

作者：

COLLIEC, S

BOISSONVIDAL, C

JOZEFONVICZ, J

机构：

[1] Laboratoire de Recherches sur les Macromolecules, CNRS URA 502, Universite Paris-Nord, 93430 Villetaneuse, Avenue J.B. Clement

来源：

PHYTOCHEMISTRY | 1994年 / 35卷 / 03期

关键词：

PELVETIA CANALICULATA; BROWN SEAWEED; SULFATED POLYSACCHARIDE; LOW MOLECULAR WEIGHT FUCOIDAN; ANTICOAGULANT;

D O I：

10.1016/S0031-9422(00)90590-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A homogeneous highly purified fucoidan fraction (F2) with a,low molecular weight was obtained by hydrolysis of crude fucoidan extracted from the brown seaweed Pelvetia canaliculata. Moreover, this fraction exhibited anticoagulant properties, and with both low viscosity and low molecular weight compatible with further in vivo experiments and clinical use, could be a promising anticoagulant agent.

引用

页码：697 / 700

页数：4

共 10 条

[1]

BERNARDI G, 1962, J BIOL CHEM, V237, P75

[2] A MODIFIED URONIC ACID CARBAZOLE REACTION [J].

BITTER, T ;

MUIR, HM .

ANALYTICAL BIOCHEMISTRY, 1962, 4 (04) :330-&

[3]

BOISSON-VIDAL C, 1991, Drugs of the Future, V16, P539

[4] COMPARISON OF ESTERASE ACTIVITIES OF TRYPSIN PLASMIN AND THROMBIN ON GUANIDINOBENZOATE ESTERS . TITRATION OF ENZYMES [J].

CHASE, T ;

SHAW, E .

BIOCHEMISTRY, 1969, 8 (05) :2212-&

[5] ANTICOAGULANT PROPERTIES OF A FUCOIDAN FRACTION [J].

COLLIEC, S ;

FISCHER, AM ;

TAPONBRETAUDIERE, J ;

BOISSON, C ;

DURAND, P ;

JOZEFONVICZ, J .

THROMBOSIS RESEARCH, 1991, 64 (02) :143-154

[6]

DISCHE Z, 1955, Methods Biochem Anal, V2, P313, DOI 10.1002/9780470110188.ch11

[7] ANTICOAGULANT ACTIVITY OF DEXTRAN DERIVATIVES .2. MECHANISM OF THROMBIN INACTIVATION [J].

FISCHER, AM ;

MAUZAC, M ;

TAPONBRETAUDIERE, J ;

JOZEFONVICZ, J .

BIOMATERIALS, 1985, 6 (03) :198-202

[8] NEW NATURAL POLYSACCHARIDES WITH POTENT ANTITHROMBIC ACTIVITY - FUCANS FROM BROWN-ALGAE [J].

GRAUFFEL, V ;

KLOAREG, B ;

MABEAU, S ;

DURAND, P ;

JOZEFONVICZ, J .

BIOMATERIALS, 1989, 10 (06) :363-368

[9] POLYANIONIC CHARACTERISTICS OF PURIFIED SULFATED HOMOFUCANS FROM BROWN-ALGAE [J].

KLOAREG, B ;

DEMARTY, M ;

MABEAU, S .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1986, 8 (06) :380-386

[10] ISOLATION, PURIFICATION, AND CHARACTERIZATION OF FUCOSE-CONTAINING SULFATED POLYSACCHARIDES FROM THE BROWN SEAWEED ECKLONIA-KUROME AND THEIR BLOOD-ANTICOAGULANT ACTIVITIES [J].

NISHINO, T ;

YOKOYAMA, G ;

DOBASHI, K ;

FUJIHARA, M ;

NAGUMO, T .

CARBOHYDRATE RESEARCH, 1989, 186 (01) :119-129

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