OLFACTORY TRANSDUCTION - CROSS-TALK BETWEEN 2ND-MESSENGER SYSTEMS

被引：71

作者：

ANHOLT, RRH

RIVERS, AM

机构：

[1] Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710

来源：

BIOCHEMISTRY | 1990年 / 29卷 / 17期

关键词：

D O I：

10.1021/bi00469a004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemosensory cilia of olfactory receptor neurons contain an adenylate cyclase which is stimulated by high concentrations of odorants. Cyclic AMP produced by this enzyme has been proposed to act as second messenger in olfactory transduction. Here we report that olfactory cilia contain calmodulin and that calmodulin potently activates olfactory adenylate cyclase by a mechanism additive to and independent from direct stimulation by odorants. Activation by calmodulin is calcium dependent and enhanced by GTP. Thus, olfactory transduction may involve a second-messenger cascade in which an odorant-induced increase in intracellular calcium concentration leads to activation of adenylate cyclase by calmodulin. © 1990, American Chemical Society. All rights reserved.

引用

收藏

页码：4049 / 4054

页数：6

相关论文

共 40 条

[1] MOLECULAR PHYSIOLOGY OF OLFACTION [J].

ANHOLT, RRH .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (06) :C1043-C1054

[2] TRANSDUCTION PROTEINS OF OLFACTORY RECEPTOR-CELLS - IDENTIFICATION OF GUANINE-NUCLEOTIDE BINDING-PROTEINS AND PROTEIN-KINASE-C [J].

ANHOLT, RRH ;

MUMBY, SM ;

STOFFERS, DA ;

GIRARD, PR ;

KUO, JF ;

SNYDER, SH .

BIOCHEMISTRY, 1987, 26 (03) :788-795

[3] PRIMARY EVENTS IN OLFACTORY RECEPTION [J].

ANHOLT, RRH .

TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (02) :58-62

[4]

ANHOLT RRH, 1986, J NEUROSCI, V6, P1962

[5] IDENTIFICATION OF A CALCIUM-BINDING PROTEIN AS A CALCIUM-DEPENDENT REGULATOR OF BRAIN ADENYLATE CYCLASE [J].

BROSTROM, CO ;

HUANG, YC ;

BRECKENRIDGE, BM ;

WOLFF, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (01) :64-68

[6] CALCIUM-DEPENDENT ADENYLATE-CYCLASE FROM RAT CEREBRAL-CORTEX - ACTIVATION BY GUANINE NUCLEOTIDES [J].

BROSTROM, MA ;

BROSTROM, CO ;

WOLFF, DJ .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1978, 191 (01) :341-350

[7]

CHEN Z, 1986, J NEUROSCI, V6, P2146

[8] REGIONAL CELLULAR AND SUBCELLULAR-DISTRIBUTION OF CALCIUM-ACTIVATED CYCLIC NUCLEOTIDE PHOSPHODIESTERASE AND CALCIUM-DEPENDENT REGULATOR IN PORCINE BRAIN [J].

EGRIE, JC ;

CAMPBELL, JA ;

FLANGAS, AL ;

SIEGEL, FL .

JOURNAL OF NEUROCHEMISTRY, 1977, 28 (06) :1207-1213

[9]

FABIATO A, 1979, J PHYSIOL-PARIS, V75, P463

[10] GATED CURRENTS IN ISOLATED OLFACTORY RECEPTOR NEURONS OF THE LARVAL TIGER SALAMANDER [J].

FIRESTEIN, S ;

WERBLIN, FS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (17) :6292-6296

← 1 2 3 4 →