THE CONTENT OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR ANTIGEN AS A PROGNOSTIC FACTOR IN URINARY-BLADDER CANCER

被引：88

作者：

HASUI, Y ^{[1
]}

MARUTSUKA, K ^{[1
]}

SUZUMIYA, J ^{[1
]}

KITADA, S ^{[1
]}

OSADA, Y ^{[1
]}

SUMIYOSHI, A ^{[1
]}

机构：

[1] MIYAZAKI MED COLL,DEPT PATHOL,MIYAZAKI 88916,JAPAN

来源：

INTERNATIONAL JOURNAL OF CANCER | 1992年 / 50卷 / 06期

关键词：

D O I：

10.1002/ijc.2910500607

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Urokinase-type plasminogen activator (u-PA) is thought to be implicated in cancer invasion and metastasis. The aim of this study was to determine whether the u-PA content of cancer tissue is a prognostic factor in bladder cancer. Tissue samples from 46 patients with bladder cancer were assessed for u-PA antigen by a highly sensitive enzyme immunoassay. The relationships between the u-PA level in extracts of bladder cancer and the survival rates of the bladder-cancer patients were examined. Patients with a high u-PA level (8 ng/mg of protein and more) showed a statistically significantly higher rate of survival than those with a low u-PA level (p < 0.005). The u-PA antigen level in cancer tissue was significantly lower in low-graded and non-invasive cancers than in others (p < 0.01).

引用

页码：871 / 873

页数：3

共 23 条

[1]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[2] IMPROVED MEDIUM FOR EXTRACTION OF PLASMINOGEN-ACTIVATOR FROM TISSUE [J].