ANTIGENICITY AND IMMUNOGENICITY OF EXPERIMENTAL EQUINE INFLUENZA ISCOM VACCINES

被引：67

作者：

MUMFORD, JA

JESSETT, D

DUNLEAVY, U

WOOD, J

HANNANT, D

SUNDQUIST, B

COOK, RF

机构：

[1] NATL INST BIOL STAND & CONTROLS,S MIMMS,HERTS,ENGLAND

[2] NATL VET INST,CTR BIOMED,DEPT VIROL,UPPSALA,SWEDEN

[3] UNIV KENTUCKY,GLUCK EQUINE RES CTR,LEXINGTON,KY 40546

来源：

VACCINE | 1994年 / 12卷 / 09期

关键词：

EQUINE INFLUENZA; ISCOM VACCINE; ANTIBODY RESPONSE;

D O I：

10.1016/0264-410X(94)90297-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A comparison of the antigenicity and immunogenicity of ISCOM vaccines prepared from equine influenza viruses H3N8 and H7N7 was made with inactivated whole-virus vaccines containing equivalent amounts of virus haemagglutinin. ISCOMs stimulated superior antibody responses in terms of both amount and duration. As with conventional whole-virus vaccines, the levels of antibody to virus haemagglutinin induced by ISCOMs correlated with protection.

引用

页码：857 / 863

页数：7

共 12 条

[1]

Burrows R, 1977, Dev Biol Stand, V39, P341

[2]

JOHN TJ, 1966, P SOC EXP BIOL MED, V121, P109, DOI 10.3181/00379727-121-30711

[3] ISCOM, A NOVEL STRUCTURE FOR ANTIGENIC PRESENTATION OF MEMBRANE-PROTEINS FROM ENVELOPED VIRUSES [J].