PROTECTION OF FERRETS AGAINST INFLUENZA CHALLENGE WITH A DNA VACCINE TO THE HEMAGGLUTININ

被引：137

作者：

WEBSTER, RG

FYNAN, EF

SANTORO, JC

ROBINSON, H

机构：

[1] UNIV MASSACHUSETTS, SCH MED, DEPT PATHOL, WORCESTER, MA 01655 USA

[2] ST JUDE CHILDRENS RES HOSP, DEPT VIROL & MOLEC BIOL, MEMPHIS, TN 38101 USA

[3] UNIV TENNESSEE, CTR HLTH SCI, DEPT PATHOL, MEMPHIS, TN 38163 USA

[4] WORCESTER STATE, DEPT NAT SCI, WORCESTER, MA 01602 USA

来源：

VACCINE | 1994年 / 12卷 / 16期

关键词：

DNA VACCINE; INFLUENZA; FERRETS;

D O I：

10.1016/0264-410X(94)90071-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunization of ferrets with a plasmid DNA expressing influenza virus haemagglutinin (pCMV/H1 DNA) provided complete protection from challenge with the homologous A/PR/8/34 (H1N1) influenza virus. Delivery of DNA-coated gold beads by gene gun to the epidermis was much more efficient than intramuscular delivery of DNA in aqueous solution. The antibody response induced by DNA delivered by gene gun was more cross-reactive than DNA delivered in aqueous solution or after natural infection. This novel approach to vaccination against influenza may afford broader protection against antigenic drift than that provided by natural infection.

引用

页码：1495 / 1498

页数：4

共 11 条

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