ALTERNARIA IGG PRECIPITINS AND ADVERSE REACTIONS

被引：14

作者：

BUSSE, WW ^{[1
]}

STORMS, WW ^{[1
]}

FLAHERTY, DK ^{[1
]}

CRANDALL, M ^{[1
]}

REED, CE ^{[1
]}

机构：

[1] UNIV WISCONSIN, DEPT MED, MADISON, WI USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 1976年 / 57卷 / 04期

关键词：

D O I：

10.1016/0091-6749(76)90094-4

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Late reactions consisting of fever, malaise and swelling at the site, 4-6 h after injections of Alternaria extract occurred in several patients receiving immunotherapy with Alternaria. These patients had in common serum IgG [immunoglobulin G] precipitins and exquisite leukocyte histamine release sensitivity to Alternaria. Such precipitins were 3 times more frequent in patients receiving Alternaria immunotherapy than a control group of patients receiving immunotherapy with other antigens. A prospective study revealed that 5 of 23 Alternaria-sensitive persons had precipitins before immunotherapy, and another 6 developed precipitins during therapy. Only 1 of the 23 experienced a late Alternaria reaction. Precipitins to Alternaria are common and do not seem to be the basis for the late reactions we observed. The findings of precipitins does not contraindicate immunotherapy.

引用

页码：367 / 372

页数：6

共 9 条

[1] LATE CUTANEOUS ALLERGIC RESPONSES IN ISOLATED IGE-DEPENDENT REACTIONS [J].