MULTIPLE ANTIGEN CHALLENGE PRODUCES PULMONARY EOSINOPHILIA BUT NOT PULMONARY HYPERRESPONSIVENESS IN ACTIVELY SENSITIZED GUINEA-PIGS

被引:9
作者
WATSON, JW
COHAN, VL
SHAY, AK
FREIERT, KW
机构
[1] Department of Immunology and Infectious Diseases, Central Research Division, Pfizer Inc, Groton, 06340, CT
来源
AGENTS AND ACTIONS | 1992年 / 37卷 / 3-4期
关键词
D O I
10.1007/BF02028101
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Exposure of actively sensitized boosted guinea pigs to aerosolized antigen, 3 times on alternate days, produced pulmonary eosinophilia but not pulmonary hyperresponsiveness to methacholine Cl measured 3 days after the last antigen challenge. These data suggest that the presence of large numbers of eosinophils in the airways and tissues of the lungs is not sufficient to produce nonspecific pulmonary hyperresponsiveness. These data also suggest that actively sensitized and boosted guinea pigs respond differently to repeated antigen exposure than do asthmatics or wild caught allergic cynomolgus monkeys.
引用
收藏
页码:174 / 177
页数:4
相关论文
共 11 条
[1]   EOSINOPHIL SUPERNATANT CAUSES HYPERRESPONSIVENESS OF AIRWAY SMOOTH-MUSCLE IN GUINEA-PIG TRACHEA [J].
AIZAWA, T ;
SEKIZAWA, K ;
AIKAWA, T ;
MARUYAMA, N ;
ITABASHI, S ;
TAMURA, G ;
SASAKI, H ;
TAKISHIMA, T .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (01) :133-137
[2]   BRONCHIAL HYPERRESPONSIVENESS AND CELLULAR INFILTRATION IN THE LUNG OF GUINEA-PIGS SENSITIZED AND CHALLENGED BY AEROSOL [J].
BOICHOT, E ;
LAGENTE, V ;
CARRE, C ;
WALTMANN, P ;
MENCIAHUERTA, JM ;
BRAQUET, P .
CLINICAL AND EXPERIMENTAL ALLERGY, 1991, 21 (01) :67-76
[3]   THE EFFECT OF THE SELECTIVE PAF ANTAGONIST BN 52021 ON PAF-INDUCED AND ANTIGEN-INDUCED BRONCHIAL HYPER-REACTIVITY AND EOSINOPHIL ACCUMULATION [J].
COYLE, AJ ;
URWIN, SC ;
PAGE, CP ;
TOUVAY, C ;
VILLAIN, B ;
BRAQUET, P .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 148 (01) :51-58
[4]   THE BOOSTER INJECTION OF ANTIGEN DURING ACTIVE SENSITIZATION OF GUINEA-PIG MODIFIES THE ANTI-ANAPHYLACTIC ACTIVITY OF THE PAF ANTAGONIST WEB 2086 [J].
DESQUAND, S ;
LEFORT, J ;
DUMAREY, C ;
VARGAFTIG, BB .
BRITISH JOURNAL OF PHARMACOLOGY, 1990, 100 (02) :217-222
[5]   HUMAN EOSINOPHIL MAJOR BASIC-PROTEIN CAUSES HYPERREACTIVITY OF RESPIRATORY SMOOTH-MUSCLE - ROLE OF THE EPITHELIUM [J].
FLAVAHAN, NA ;
SLIFMAN, NR ;
GLEICH, GJ ;
VANHOUTTE, PM .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 138 (03) :685-688
[6]   PREVENTION OF NON-SPECIFIC AIRWAY HYPERREACTIVITY AFTER ALLERGEN CHALLENGE IN GUINEA-PIGS BY THE PAF RECEPTOR ANTAGONIST SDZ 64-412 [J].
HAVILL, AM ;
VANVALEN, RG ;
HANDLEY, DA .
BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (02) :396-400
[7]   NON-INVASIVE TECHNIQUE FOR MEASUREMENT OF CHANGES IN SPECIFIC AIRWAY-RESISTANCE [J].
PENNOCK, BE ;
COX, CP ;
ROGERS, RM ;
CAIN, WA ;
WELLS, JH .
JOURNAL OF APPLIED PHYSIOLOGY, 1979, 46 (02) :399-406
[8]  
WATSON JW, 1986, J APPL PHYSIOL, V61, P304, DOI 10.1152/jappl.1986.61.1.304
[9]   IGG1-MEDIATED ACUTE PULMONARY HYPERSENSITIVITY RESPONSE IN THE GUINEA-PIG - INVOLVEMENT OF SPECIFIC LIPID MEDIATORS [J].
WATSON, JW ;
CONKLYN, M ;
SHOWELL, HJ .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (05) :1093-1098
[10]  
WEGNER C D, 1989, American Review of Respiratory Disease, V139, pA324