A PRACTICAL AND GENERAL-SYNTHESIS OF (+)-CARBOXYALKYLDEOXOARTEMISININS

被引：26

作者：

JUNG, M

FREITAS, ACC

MCCHESNEY, JD

ELSOHLY, HN

机构：

[1] UNIV MISSISSIPPI, SCH PHARM, DEPT MED CHEM, UNIVERSITY, MS 38677 USA

[2] UNIV MISSISSIPPI, SCH PHARM, DEPT PHARMACOGNOSY, UNIVERSITY, MS 38677 USA

来源：

HETEROCYCLES | 1994年 / 39卷 / 01期

关键词：

D O I：

10.3987/COM-93-S(B)9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dye-sensitized photoxygenation of olefinic alcohols of dihydroartemisinates (4a-c) and direct oxidation of olefinic deoxoartemisinins (5a-c) have led to the preparation of carboxyalkyldeoxoartemisinins (6a-c), which are water-soluble and chemically more stable antimalarial agents.

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页码：23 / 29

页数：7

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