LCH-I - A RANDOMIZED TRIAL OF ETOPOSIDE VS VINBLASTINE IN DISSEMINATED LANGERHANS CELL HISTIOCYTOSIS

被引：100

作者：

LADISCH, S

GADNER, H

ARICO, M

BROADBENT, V

GROIS, N

JACOBSON, A

KOMP, D

NICHOLSON, HS

机构：

[1] ST ANNA CHILDRENS HOSP,VIENNA,AUSTRIA

[2] POLICLIN SAN MATTEO,PAVIA,ITALY

[3] YALE UNIV,NEW HAVEN,CT 06520

[4] ADDENBROOKES HOSP,CAMBRIDGE CB2 2QQ,ENGLAND

[5] UNIV UPPSALA,S-75105 UPPSALA,SWEDEN

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1994年 / 23卷 / 02期

关键词：

SECONDARY MALIGNANCIES; EPIPODOPHYLLOTOXIN; MONOCYTE-MACROPHAGE SYSTEM;

D O I：

10.1002/mpo.2950230207

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An international randomized trial in Langerhans cell histiocytosis (LCH) has been initiated by the Histiocyte Society. This report reviews the rationale, design, and progress of LCH-I, which compares etoposide (VP-16) and vinblastine in the treatment of disseminated LCH. Data on the risk of etoposide-associated (therapy-induced) malignancy, in the setting of histiocytosis, are reviewed. The available evidence leads to the recommendation that the study of etoposide in LCH should be continued. (C) 1994 Wiley-Liss, Inc.

引用

页码：107 / 110

页数：4

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