AMINO-ACID-SEQUENCE OF TOXIN-VII, A BETA-TOXIN FROM THE VENOM OF THE SCORPION TITYUS-SERRULATUS

被引:62
作者
BECHIS, G
SAMPIERI, F
YUAN, PM
BRANDO, T
MARTIN, MF
DINIZ, CR
ROCHAT, H
机构
[1] BECKMAN INSTRUMENTS INC, SPINCO DIV, PALO ALTO, CA USA
[2] UNIV FED MINAS GERAIS, INST CIENCIAS BIOL, DEPT BIOQUIM & IMMUNOL, BR-30000 BELO HORIZONTE, MG, BRAZIL
关键词
D O I
10.1016/0006-291X(84)91211-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The sequence of the 61 amino acids of toxin VII, a .beta.-toxin from the venom of the South American scorpion T. serrulatus, was determined by automatic sequencing of the reduced and S-[14C] carboxymethylated protein and of tryptic peptides obtained before or after citraconylation of this protein. This toxin, the most active .beta.-toxin from this venom, is the first Tityus toxin to be fully sequenced. Toxin VII belongs to the structural group of scorpion toxins originating from Central and North America.
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收藏
页码:1146 / 1153
页数:8
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