DEGRADATION KINETICS OF DILTIAZEM

被引：7

作者：

SULEIMAN, MS

ABDULHAMEED, ME

NAJIB, NM

MUTI, HY

机构：

[1] DAR AL DAWA DEV & INVESTEMENT CO LTD,DEPT RES & DEV,NAUR,JORDAN

[2] JORDAN UNIV SCI & TECHNOL,FAC PHARM,DEPT MED CHEM,IRBID,JORDAN

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 04期

关键词：

D O I：

10.3109/03639049009104411

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The kinetics of degradation of diltiazem hydrochloride in aqueous buffered solutions (pH 1-7) were studied. Diltiazem was found to undergo hydrolysis to desacetyldiltiazem. The decomposition of diltiazem followed pseudo-first order kinetics under the experimental conditions. The drug was relatively stable over the pH range 3-6 with optimum stability at pH 5. The extrapolated shelf-life at this pH was 42.0 days compared to 15.8 day at pH 2. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：685 / 694

页数：10

共 8 条

[1]

ABDELHAMEED EM, 1988, UNPUB

[2] BENEFICIAL EFFECT OF INTRAVENOUS DILTIAZEM IN THE ACUTE MANAGEMENT OF PAROXYSMAL SUPRA-VENTRICULAR TACHYARRHYTHMIAS [J].