BEAD COATING .2. EFFECT OF SPHERONIZATION TECHNIQUE ON DRUG RELEASE FROM COATED SPHERES

被引：16

作者：

ZHANG, GH ^{[1
]}

SCHWARTZ, JB ^{[1
]}

SCHNAARE, RL ^{[1
]}

WIGENT, RJ ^{[1
]}

SUGITA, ET ^{[1
]}

机构：

[1] PHILADELPHIA COLL PHARM & SCI,DEPT PHARMACEUT,PHILADELPHIA,PA 19104

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 06期

关键词：

D O I：

10.3109/03639049109040820

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of spheronization method on drug release from coated spheres may be evaluated by determining the drug release rate, the critical coating level and the release mechanism. Drug release is faster from pan beads than from marumerizer beads at the same coating level. An equation is proposed which indicates that the critical coating level is inversely proportional to sphere size and sphere density, which in turn results from the different spheronization techniques. From the calculation, the critical coating levels for 14/16 mesh cuts of marumerizer beads and pan beads are 12% and 18%, respectively. Disintegration, pore-control and barrier control are involved in the release mechanisms of drugs from coated pan beads.

引用

页码：817 / 830

页数：14

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