EFFICIENT MICHAEL ADDITION-REACTIONS OF THE N-ARYLSULFONYL-3-PHENYLTHIOPIPERIDONES - SYNTHESIS OF 3-SUBSTITUTED DIHYDROPYRIDINONES

被引：13

作者：

NAKAGAWA, M

TORISAWA, Y

HOSAKA, T

TANABE, K

TAVET, F

AIKAWA, M

HINO, T

机构：

[1] Faculty of Pharmaceutical Sciences, Chiba University 1-33, Inage-ku, Chiba-shi, 263, Yayoi-cho

来源：

HETEROCYCLES | 1993年 / 35卷 / 02期

关键词：

D O I：

10.3987/COM-92-S(T)117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient methods for the Michael addition reactions of N-arylsulfonyl-3-phenylthiopiperidones (1) with both the protected amidoacrylates (4, 9) and the simple acrylates (12) have been developed. These reactions offer an efficient route to the 3-alkyl-substituted dihydropyridinones (3, 11), the dienophiles employed in the natural product synthesis.

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页码：1157 / 1170

页数：14

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