A ROLE FOR CD5 IN TCR-MEDIATED SIGNAL-TRANSDUCTION AND THYMOCYTE SELECTION

被引：382

作者：

TARAKHOVSKY, A

KANNER, SB

HOMBACH, J

LEDBETTER, JA

MULLER, W

KILLEEN, N

RAJEWSKY, K

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST, SEATTLE, WA 98121 USA

[2] UNIV ZURICH, DEPT PATHOL, INST EXPTL IMMUNOL, CH-8091 ZURICH, SWITZERLAND

[3] UNIV CALIF SAN FRANCISCO, DEPT MICROBIOL & IMMUNOL, SAN FRANCISCO, CA 94143 USA

来源：

SCIENCE | 1995年 / 269卷 / 5223期

关键词：

D O I：

10.1126/science.7542801

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.

引用

页码：535 / 537

页数：3

共 35 条

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