SELECTIVE BROMINATION OF KETONES - A CONVENIENT SYNTHESIS OF 5-AMINOLEVULINIC ACID

被引：50

作者：

HA, HJ

LEE, SK

HA, YJ

PARK, JW

机构：

[1] Department of Chemistry, Hankuk University of Foreign Studies, Yongin-Gun, Kyunggi-Do

来源：

SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 18期

关键词：

D O I：

10.1080/00397919408010567

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bromination of unsymmetrical ketones with Br-2 in methanol proceeded regioselectively in good yield at the less substituted methyl carbon. The bromination of levulinic acid using this method was followed by azidation and amination to lead to an efficient three-step synthesis of 5-aminolevulinic acid in 36% overall yield.

引用

页码：2557 / 2562

页数：6

共 20 条

[1]

AWRUCH J, 1976, Tetrahedron Letters, V46, P4121

[2] CHEMICAL SYNTHESIS OF 4,5-DIOXOVALERIC ACID AND ITS NON-ENZYMATIC TRANSAMINATION TO 5-AMINOLEVULINIC ACID [J].