ANTI-GAL-C ANTIBODY IN AUTOIMMUNE NEUROPATHIES SUBSEQUENT TO MYCOPLASMA-INFECTION

被引：73

作者：

KUSUNOKI, S ^{[1
]}

CHIBA, A ^{[1
]}

HITOSHI, S ^{[1
]}

TAKIZAWA, H ^{[1
]}

KANAZAWA, I ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT MED & PHYS THERAPY,TOKYO 113,JAPAN

来源：

MUSCLE & NERVE | 1995年 / 18卷 / 04期

关键词：

GUILLAIN-BARRE SYNDROME; MULTIFOCAL MOTOR NEUROPATHY; GALACTOCEREBROSIDE; GANGLIOSIDE; MYCOPLASMA PNEUMONIAE;

D O I：

10.1002/mus.880180407

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Four of 82 patients with Guillain-Barre syndrome (GBS) and 1 of 12 with multifocal motor neuropathy (MMN), who previously had had Mycoplasma pneumoniae infections, had serum antibody to galactocerebroside (Gal-C). Two patients with GBS without mycoplasma infection also had anti-Gal-C antibody, whereas none of the normal or the disease controls had it. As Gal-C is a major glycolipid antigen in myelin, anti-Gal-C antibody may function in the pathogenesis of autoimmune demyelinative neuropathies, Mycoplasma pneumoniae appears to be an important preceding infectious agent in autoimmune neuropathies with anti-Gal-C antibody. (C) 1995 John Wiley and Sons, Inc.

引用

页码：409 / 413

页数：5

共 18 条

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