SYNTHESES OF TREHAZOLIN DERIVATIVES AND EVALUATION AS GLYCOSIDASE INHIBITORS

被引：40

作者：

KOBAYASHI, Y

SHIOZAKI, M

机构：

[1] SANKYO CO LTD,EXPLORATORY CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

[2] SANKYO CO LTD,BIOMED RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 08期

关键词：

D O I：

10.1021/jo00113a041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The trehazolin derivatives 9-12 were synthesized from the aminocyclitol (7), which is the degradation product of trehazolin (5). In particular, compounds 9-11 were pseudodisaccharides that underwent replacement of the corresponding nonreducing D-glucose moieties of isomaltose and maltose by trehalamine (6), and they were designed to be therapeutic drugs; however, they did not show significant activities.

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页码：2570 / 2580

页数：11

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