CORRELATION OF RATIOS OF DRUG METABOLISM BY MICROSOMAL SUBFRACTIONS WITH PARTITION COEFFICIENTS

被引：13

作者：

LIEN, EJ

HANSCH, C

机构：

[1] Seaver Chemistry Laboratory, Pomona College, Claremont, California

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 06期

关键词：

Drug metabolism—microsomal subfractions; Metabolism—partition coefficient ratios—correlated; Microsomal particles; smooth; rough—metabolism rates;

D O I：

10.1002/jps.2600570625

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A strong correlation between ratios of drug metabolism by microsomal subfractions with 1‐octanol/water partition coefficient was found. Explanation for the spread of ratios is presented. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1027 / &

共 14 条

[1] ENZYMATIC METABOLISM OF DRUGS AND OTHER FOREIGN COMPOUNDS [J].

BRODIE, BB ;

GILLETTE, JR ;

LADU, BN .

ANNUAL REVIEW OF BIOCHEMISTRY, 1958, 27 :427-454

[2] METABOLISM OF DRUGS BY SUBFRACTIONS OF HEPATIC MICROSOMES [J].

FOUTS, JR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1961, 6 (05) :373-&

[3]

FOUTS JR, 1962, 1 P INT PHARM M, P257

[4] NEW SUBSTITUENT CONSTANT PI DERIVED FROM PARTITION COEFFICIENTS [J].

FUJITA, T ;

HANSCH, C ;

IWASA, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (23) :5175-&

[5]

GRAM TE, 1966, J PHARMACOL EXP THER, V152, P363

[6]

GRAM TE, 1967, J PHARMACOL EXP THER, V155, P479

[7] HYDROXYLATION-INDUCED MIGRATION - NIH SHIFT [J].

GUROFF, G ;

DALY, JW ;

JERINA, DM ;

RENSON, J ;

WITKOP, B ;

UDENFRIE.S .

SCIENCE, 1967, 157 (3796) :1524-&

[8]

HANSCH C, 1965, MOL PHARMACOL, V1, P205

[9] RHO-SIGMA-PI ANALYSIS . METHOD FOR CORRELATION OF BIOLOGICAL ACTIVITY + CHEMICAL STRUCTURE [J].

HANSCH, C ;

FUJITA, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) :1616-&

[10] EFFECT OF INTRAMOLECULAR HYDROPHOBIC BONDING ON PARTITION COEFFICIENTS [J].

HANSCH, C ;

ANDERSON, SM .

JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (08) :2583-&

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