REGIOSELECTIVE ENOLIZATION OF OPTICALLY-ACTIVE 3-KETO STEROIDS USING CHIRAL LITHIUM AMIDES

被引：29

作者：

SOBUKAWA, M

NAKAJIMA, M

KOGA, K

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN

[2] TANABE SEIYAKU CO LTD,ORGAN CHEM RES LAB,TODA,SAITAMA 335,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1990年 / 1卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)86317-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Deprotonation of optically active 3-keto steroids (1, 2, 10, 11) by chiral lithium amides ((R)- or (S)-5) in the presence of excess trimethylsilyl chloride gave either regioisomers of their corresponding trimethylsilyl enol ethers in reasonably high selectivities. © 1990.

引用

页码：295 / 298

页数：4

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[1]

BROWNBRIDGE P, 1983, SYNTHESIS-STUTTGART, P85

[2]

BROWNBRIDGE P, 1983, SYNTHESIS-STUTTGART, P1

[3]

COLVIN EW, 1988, SILICON REAGENTS ORG, P99

[4] HIGHLY SELECTIVE, KINETICALLY CONTROLLED ENOLATE FORMATION USING LITHIUM DIALKYLAMIDES IN THE PRESENCE OF TRIMETHYLCHLOROSILANE [J].