REENTRY OF T-CELLS TO THE ADULT THYMUS IS RESTRICTED TO ACTIVATED T-CELLS

被引:267
作者
AGUS, DB [1 ]
SURH, CD [1 ]
SPRENT, J [1 ]
机构
[1] Scripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
关键词
D O I
10.1084/jem.173.5.1039
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
To seek information on the capacity of mature T cells to migrate to the thymus, mice were injected with Thy-1-marked populations enriched for resting T cells or T blast cells; localization of the donor cells in the host thymus was assessed by staining cryostat sections of thymus and by FACS(R) analysis of cell suspensions. With injection of purified resting T cells, thymic homing was extremely limited, even with injection of large doses of cells. By contrast, in vivo generated T blast cells migrated to the thymus in substantial numbers. Thymic homing by T blasts was > 50-fold more efficient than with resting T cells. Blast cells localized largely in the medulla and remained in the thymus for at least 1 mo post-transfer. Interestingly, localization of T blasts in the thymus was 10-fold higher in irradiated hosts than normal hosts. Thymic homing was especially prominent in mice injected with T blasts incubated in vitro with the DNA precursor, I-125-5-iodo-2'deoxyuridine (IDUR)-I-125; with transfer of (IDUR)-I-125-labeled blasts to irradiated hosts, up to 5% of the injected counts localized in the host thymus. These data suggest that thymic homing by T blasts might be largely restricted to cells in S phase. The physiological significance of blast cell entry to the thymus is unclear. The possibility that these cells participate in intrathymic tolerance induction is discussed.
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页码:1039 / 1046
页数:8
相关论文
共 25 条
[1]
IMMUNOLOGICAL STUDIES OF T-CELL RECEPTORS .2. LIMITED POLYMORPHISM OF IDIOTYPIC DETERMINANTS ON T-CELL RECEPTORS SPECIFIC FOR MAJOR HISTOCOMPATIBILITY COMPLEX ALLOANTIGENS [J].
BELLGRAU, D ;
WILSON, DB .
JOURNAL OF EXPERIMENTAL MEDICINE, 1979, 149 (01) :234-243
[2]
MOUSE LEUKEMIA - THERAPY WITH MONOCLONAL-ANTIBODIES AGAINST A THYMUS DIFFERENTIATION ANTIGEN [J].
BERNSTEIN, ID ;
TAM, MR ;
NOWINSKI, RC .
SCIENCE, 1980, 207 (4426) :68-71
[3]
BRUCE J, 1981, J IMMUNOL, V127, P2496
[4]
BUTCHER EC, 1979, J IMMUNOL, V123, P1996
[5]
CHARACTERIZATION OF THE MURINE ANTIGENIC DETERMINANT, DESIGNATED L3T4A, RECOGNIZED BY MONOCLONAL-ANTIBODY GK1.5 - EXPRESSION OF L3T4A BY FUNCTIONAL T-CELL CLONES APPEARS TO CORRELATE PRIMARILY WITH CLASS II MHC ANTIGEN-REACTIVITY [J].
DIALYNAS, DP ;
WILDE, DB ;
MARRACK, P ;
PIERRES, A ;
WALL, KA ;
HAVRAN, W ;
OTTEN, G ;
LOKEN, MR ;
PIERRES, M ;
KAPPLER, J ;
FITCH, FW .
IMMUNOLOGICAL REVIEWS, 1983, 74 :29-56
[6]
SPECIFIC BINDING OF RADIOLABELED MEMBRANE-VESICLES BY T-CELLS ACTIVATED IN THE MIXED LYMPHOCYTE-REACTION [J].
ELLIOTT, BE ;
TAKACS, B ;
NAGY, Z .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1979, 9 (08) :646-651
[7]
THYMIC CYTO-TOXIC LYMPHOCYTES-T ARE PRIMED INVIVO TO MINOR HISTOCOMPATIBILITY ANTIGENS [J].
FINK, PJ ;
BEVAN, MJ ;
WEISSMAN, IL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 159 (02) :436-451
[8]
THYMUS - A DIRECT TARGET TISSUE IN GRAFT-VERSUS-HOST REACTION AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION THAT RESULTS IN ABROGATION OF INDUCTION OF SELF-TOLERANCE [J].
FUKUSHI, N ;
ARASE, H ;
WANG, BY ;
OGASAWARA, K ;
GOTOHDA, T ;
GOOD, RA ;
ONOE, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) :6301-6305
[9]
ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN RAT [J].
GOWANS, JL ;
KNIGHT, EJ .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1964, 159 (975) :257-+
[10]
IMMUNOHISTOLOGICAL ANALYSIS OF IMMIGRATION OF THYMOCYTE-PRECURSORS INTO THE THYMUS - EVIDENCE FOR IMMIGRATION OF PERIPHERAL T-CELLS INTO THE THYMIC MEDULLA [J].
HIROKAWA, K ;
UTSUYAMA, M ;
SADO, T .
CELLULAR IMMUNOLOGY, 1989, 119 (01) :160-170