THE FUNCTIONAL-ROLE OF THE BETA-SUBUNIT IN THE MATURATION AND INTRACELLULAR-TRANSPORT OF NA,K-ATPASE

被引：198

作者：

GEERING, K

机构：

[1] Institut de Pharmacologie et Toxicologie, Université de Lausanne

来源：

FEBS LETTERS | 1991年 / 285卷 / 02期

关键词：

NA-K-ATPASE; ADENOSINE TRIPHOSPHATASE; BETA-SUBUNIT; PROTEIN OLIGOMERIZATION; SUBUNIT ASSEMBLY; MATURATION; INTRACELLULAR TRANSPORT;

D O I：

10.1016/0014-5793(91)80801-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The minimal functional enzyme unit of Na,K-ATPase consists of an alpha-beta-complex. The alpha-subunit bears all functional domains of the enzyme and so far a regulatory role for the beta-subunit in the catalytic cycle has not been established. On the other hand, increasing experimental evidence suggests that the beta-subunit is an indispensable element for the structural and functional maturation of the enzyme as well as its intracellular transport to the plasma membrane. This brief review summarizes the experimental data supporting the hypothesis that assembly of the beta-subunit is needed for the alpha-subunit to acquire the correct, stable configuration necessary for the acquisition of functional properties and its exit from the ER.

引用

页码：189 / 193

页数：5

共 66 条

[1] MUTUAL DEPENDENCE OF NA,K-ATPASE ALPHA-SUBUNITS AND BETA-SUBUNITS FOR CORRECT POSTTRANSLATIONAL PROCESSING AND INTRACELLULAR-TRANSPORT
ACKERMANN, U
GEERING, K
[J]. FEBS LETTERS, 1990, 269 (01): : 105 - 108
[2] MOLECULAR-CLONING OF THE BETA-SUBUNIT OF THE NA,K-ATPASE IN THE BRINE SHRIMP, ARTEMIA - THE CDNA-DERIVED AMINO-ACID-SEQUENCE SHOWS LOW HOMOLOGY WITH THE BETA-SUBUNITS OF VERTEBRATES EXCEPT IN THE SINGLE TRANSMEMBRANE AND THE CARBOXY-TERMINAL DOMAINS
BHATTACHARYYA, KK
BERGSTROM, EE
HOKIN, LE
[J]. FEBS LETTERS, 1990, 269 (01): : 233 - 238
[3] MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF THE (NA+ + K+)-ATPASE BETA-SUBUNIT FROM DOG KIDNEY
BROWN, TA
HOROWITZ, B
MILLER, RP
MCDONOUGH, AA
FARLEY, RA
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 912 (02) : 244 - 253
[4] CANFIELD VA, 1990, J BIOL CHEM, V265, P19878
[5] CAPLAN MJ, 1990, J BIOL CHEM, V265, P3528
[6] CAPLAN MJ, 1986, J BIOL CHEM, V261, P2860
[7] CAYANIS E, 1990, J BIOL CHEM, V265, P10829
[8] ASYMMETRIC ORIENTATION OF AMINO-GROUPS IN THE ALPHA-SUBUNIT AND THE BETA-SUBUNIT OF (NA++K+)-ATPASE IN TIGHT RIGHT-SIDE-OUT VESICLES OF BASOLATERAL MEMBRANES FROM OUTER MEDULLA
DZHANDZHUGAZYAN, KN
JORGENSEN, PL
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 817 (01) : 165 - 173
[9] EMANUEL JR, 1988, J BIOL CHEM, V263, P7726
[10] ORIENTATION OF THE BETA-SUBUNIT POLYPEPTIDE OF (NA+ +K+)ATPASE IN THE CELL-MEMBRANE
FARLEY, RA
MILLER, RP
KUDROW, A
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 873 (01) : 136 - 142

← 1 2 3 4 5 6 7 →