CONJUNCTIVAL EPITHELIAL-CELLS FROM PATIENTS WITH SJOGRENS-SYNDROME INAPPROPRIATELY EXPRESS MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES, LA(SSB) ANTIGEN, AND HEAT-SHOCK PROTEINS

被引：51

作者：

YANNOPOULOS, DI

RONCIN, S

LAMOUR, A

PENNEC, YL

MOUTSOPOULOS, HM

YOUINOU, P

机构：

[1] BREST UNIV,SCH MED,IMMUNOL LAB,BREST,FRANCE

[2] BREST UNIV,SCH MED,OPHTHALMOL UNIT,BREST,FRANCE

[3] BREST UNIV,SCH MED,BREST,FRANCE

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1992年 / 12卷 / 04期

关键词：

SJOGRENS SYNDROME; LA(SSB) ANTIGEN; EPITHELIAL CELLS;

D O I：

10.1007/BF00918149

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The La(SSB) antigen has been detected within the cytoplasm and on the membrane of conjunctival cells (CC) from patients with Sjogren's syndrome, whereas it was weakly expressed in the nucleus of normal cells. The diseased CC were shown to overproduce major histocompatibility complex (MHC) class I antigens and express MHC class II antigens. Anti-heat-shock protein monoclonal antibody bound to the cell membrane in patients but not in normal controls.

引用

页码：259 / 265

页数：7

共 20 条

[1]

BABOONIAN C, 1989, CLIN EXP IMMUNOL, V78, P454

[2] TRANSLOCATION OF THE NUCLEAR AUTOANTIGEN LA TO CELL-SURFACE - ASSEMBLY AND DISASSEMBLY WITH THE EXTRACELLULAR-MATRIX [J].