In psoriasis, the earliest observable electronic microscopic changes are in the dermal papillary vasculature. The flashlamp-pumped pulsed tunable dye laser can achieve selective photothermolysis of the dermal vasculature. This laser was used to treat eight patients with chronic plaque psoriasis, as it was hypothesized that the ablation of dermal papillary vasculature would arrest the early events leading to the evolution of psoriasis, and produce resolution of the plaques. At the final assessment, performed 10 weeks after three fortnightly laser treatments, five of the eight patients recorded an improvement of greater than or equal to 50%, and one showed complete resolution of the treated plaques of psoriasis. Although not practicable in the treatment of widespread psoriasis, we conclude that selective photothermolysis of the dermal vasculature by pulsed tunable dye laser offers an alternative new therapy for chronic plaque psoriasis, and also demonstrates the pivotal role of the vasculature in the pathogenesis of psoriasis.
机构:
VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343
HENG, MCY
;
ALLEN, SG
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VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343
ALLEN, SG
;
HABERFELDE, G
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机构:
VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343
HABERFELDE, G
;
SONG, MK
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h-index: 0
机构:
VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343
机构:
VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343
HENG, MCY
;
ALLEN, SG
论文数: 0引用数: 0
h-index: 0
机构:
VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343
ALLEN, SG
;
HABERFELDE, G
论文数: 0引用数: 0
h-index: 0
机构:
VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343
HABERFELDE, G
;
SONG, MK
论文数: 0引用数: 0
h-index: 0
机构:
VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343VET ADM MED CTR,SAN FERNANDO VALLEY INTERNAL MED PROGRAM,SEPULVEDA,CA 91343