DIFFERENTIAL EXPRESSION OF 2 ZEBRAFISH EMX HOMEOPROTEIN MESSENGER-RNAS IN THE DEVELOPING BRAIN

被引：112

作者：

MORITA, T ^{[1
]}

NITTA, H ^{[1
]}

KIYAMA, Y ^{[1
]}

MORI, H ^{[1
]}

MISHINA, M ^{[1
]}

机构：

[1] UNIV TOKYO, FAC MED, DEPT PHARMACOL, BUNKYO KU, TOKYO 113, JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 198卷 / 02期

关键词：

EMX HOMEOPROTEIN; ZEBRAFISH; BRAIN DEVELOPMENT; TELENCEPHALON; DIENCEPHALON;

D O I：

10.1016/0304-3940(95)11988-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The complete amino-acid sequences of two zebrafish emr homeoproteins containing a homeodomain homologous to that of the Drosophila empty spiracles head gap gene product have been determined by cloning and sequencing of cDNAs. The zebrafish emx1 and emx2 homeoproteins consist of 233 and 247 amino acids, respectively. The zebrafish emx1 and emx2 mRNAs are present at 12 h after fertilization, when the presumptive brain is in a simple tubular structure, and before first primary neurons appear. During brain development, the emx1 mRNA is localized in the dorsal telencephalon, whereas the emx2 mRNA is distributed in the dorsal telencephalon, parts of the diencephalon and the otocyst. The differential expression patterns of the two emr homeoprotein mRNAs may define the subdivisions of the zebrafish telencephalon.

引用

页码：131 / 134

页数：4

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