PREVENTION OF PYELONEPHRITIS BY IMMUNIZATION WITH P-FIMBRIAE

被引：94

作者：

ROBERTS, JA

HARDAWAY, K

KAACK, B

FUSSELL, EN

BASKIN, G

机构：

[1] DELTA REG PRIMATE RES CTR, DEPT UROL, COVINGTON, LA 70433 USA

[2] DELTA REG PRIMATE RES CTR, DEPT PATHOL, COVINGTON, LA 70433 USA

[3] TULANE UNIV, SCH MED, NEW ORLEANS, LA 70112 USA

来源：

JOURNAL OF UROLOGY | 1984年 / 131卷 / 03期

关键词：

D O I：

10.1016/S0022-5347(17)50513-3

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

[Pyelonephritic D-mannose resistant] P-fimbriae is a virulence factor in human and nonhuman primate urinary tract infections caused by Escherichia coli, because of bacterial adherence to urothelial cells which is mediated by adherence of fimbriae to a specific glycolipid receptor on the cell membrane of these cells. P-fimbriae was purified for immunization of monkeys [Macaca fascicularis]. High titers of antifimbrial antibody protected against acute and chronic pyelonephritis after renal inoculations of P-fimbriated E. coli.

引用

页码：602 / 607

页数：6

共 21 条

[1]

BEACHEY EH, 1980, BACTERIAL ADHERENC B, P6

[2]

JANSON KL, 1978, INVEST UROL, V15, P397

[3] PROTECTION AGAINST ASCENDING ESCHERICHIA-COLI PYELONEPHRITIS IN RATS AND SIGNIFICANCE OF LOCAL IMMUNITY [J].