CRYSTAL-STRUCTURE AT 1.7-ANGSTROM OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET

被引：304

作者：

HEGDE, RS

GROSSMAN, SR

LAIMINS, LA

SIGLER, PB

机构：

[1] YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06510

[2] UNIV CHICAGO,DEPT MOLEC GENET & CELL BIOL,CHICAGO,IL 60637

[3] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637

来源：

NATURE | 1992年 / 359卷 / 6395期

关键词：

D O I：

10.1038/359505a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The dominant transcriptional regulator of the papillomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric antiparallel beta-barrel. The DNA is severely but smoothly bent over the barrel by the interaction of successive major grooves with a pair of symmetrically disposed alpha-helices. The specific interface is an 'interwoven' network of interactions where the identifying base pairs of the target contact more than one amino-acid side chain and the discriminating amino acids interact with more than one base pair.

引用

页码：505 / 512

页数：8

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