ANIMAL-MODELS OF HUMAN GENETIC-DISEASES

被引：88

作者：

SMITHIES, O

机构：

[1] Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill

来源：

TRENDS IN GENETICS | 1993年 / 9卷 / 04期

关键词：

D O I：

10.1016/0168-9525(93)90204-U

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene targeting in cultured embryonic stem cells permits the generation of mice with a desired alteration in a chosen target gene. Application of this procedure to create mouse models of human diseases is revealing the innate complexity of diseases normally ascribed to single gene defects. Modeling human diseases that are known to be multigenic in origin and are markedly influenced by environmental factors is potentially even more revealing.

引用

收藏

页码：112 / 117

页数：6

相关论文

共 27 条

[1] ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].

CAPECCHI, MR .

SCIENCE, 1989, 244 (4910) :1288-1292

[2] DEFECTIVE EPITHELIAL CHLORIDE TRANSPORT IN A GENE-TARGETED MOUSE MODEL OF CYSTIC-FIBROSIS [J].

CLARKE, LL ;

GRUBB, BR ;

GABRIEL, SE ;

SMITHIES, O ;

KOLLER, BH ;

BOUCHER, RC .

SCIENCE, 1992, 257 (5073) :1125-1128

[3] CYSTIC-FIBROSIS MOUSE WITH INTESTINAL-OBSTRUCTION [J].

COLLEDGE, WH ;

RATCLIFF, R ;

FOSTER, D ;

WILLIAMSON, R ;

EVANS, MJ .

LANCET, 1992, 340 (8820) :680-680

[4] CYSTIC-FIBROSIS IN THE MOUSE BY TARGETED INSERTIONAL MUTAGENESIS [J].

DORIN, JR ;

DICKINSON, P ;

ALTON, EWFW ;

SMITH, SN ;

GEDDES, DM ;

STEVENSON, BJ ;

KIMBER, WL ;

FLEMING, S ;

CLARKE, AR ;

HOOPER, ML ;

ANDERSON, L ;

BEDDINGTON, RSP ;

PORTEOUS, DJ .

NATURE, 1992, 359 (6392) :211-215

[5]

Dorin Julia R., 1992, Transgenic Research, V1, P101, DOI 10.1007/BF02513027

[6] CANINE HEMOPHILIA-B RESULTING FROM A POINT MUTATION WITH UNUSUAL CONSEQUENCES [J].

EVANS, JP ;

BRINKHOUS, KM ;

BRAYER, GD ;

REISNER, HM ;

HIGH, KA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :10095-10099

[7] ESTABLISHMENT IN CULTURE OF PLURIPOTENTIAL CELLS FROM MOUSE EMBRYOS [J].

EVANS, MJ ;

KAUFMAN, MH .

NATURE, 1981, 292 (5819) :154-156

[8] INTRODUCTION OF A SUBTLE MUTATION INTO THE HOX-2.6 LOCUS IN EMBRYONIC STEM-CELLS [J].

HASTY, P ;

RAMIREZSOLIS, R ;

KRUMLAUF, R ;

BRADLEY, A .

NATURE, 1991, 350 (6315) :243-246

[9] RECOMBINANT FRAGMENT ASSAY FOR GENE TARGETTING BASED ON THE POLYMERASE CHAIN-REACTION [J].

KIM, HS ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1988, 16 (18) :8887-8903

[10] ALTERING GENES IN ANIMALS BY GENE TARGETING [J].

KOLLER, BH ;

SMITHIES, O .

ANNUAL REVIEW OF IMMUNOLOGY, 1992, 10 :705-730