CLONING OF AN ADENOSINE-A1 RECEPTOR-ENCODING GENE FROM RABBIT

被引：31

作者：

BHATTACHARYA, S

DEWITT, DL

BURNATOWSKAHLEDIN, M

SMITH, WL

SPIELMAN, WS

机构：

[1] MICHIGAN STATE UNIV,DEPT PHYSIOL,E LANSING,MI 48824

[2] MICHIGAN STATE UNIV,DEPT BIOCHEM,E LANSING,MI 48824

来源：

GENE | 1993年 / 128卷 / 02期

关键词：

CDNA AND GENOMIC LIBRARIES; G-PROTEINS; NUCLEOTIDE AND AMINO ACID SEQUENCES; INTRONS;

D O I：

10.1016/0378-1119(93)90576-O

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A partial cDNA encoding the Al adenosine receptor (A1AR), which lacks nucleotides coding for the first 74 amino acids (aa), was isolated from a rabbit kidney cDNA library. The missing 5' end sequence was obtained from an overlapping rabbit genomic clone which was found to contain the flanking 5' untranslated region (5'UTR), the first exon and part of the first intron. Together, the cDNA and genomic clones provide the entire open reading frame (ORF) encoding rabbit A1AR. The deduced aa sequence is highly homologous to the canine, rat and bovine A1ARs. These data also indicate that the A1AR gene belongs to the family of intron-containing G-protein-linked receptor genes.

引用

页码：285 / 288

页数：4

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