CHLORIDE SECRETION AND FUNCTION OF SEROUS AND MUCOUS CELLS OF HUMAN AIRWAY GLANDS

被引：43

作者：

FINKBEINER, WE

SHEN, BQ

WIDDICOMBE, JH

机构：

[1] UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT PATHOL,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1994年 / 267卷 / 02期

关键词：

CYSTIC FIBROSIS; USSING CHAMBERS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR;

D O I：

10.1152/ajplung.1994.267.2.L206

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Cells from the acini of human tracheal glands were grown in culture to produce confluent cell sheets of mucous or mixed seromucous phenotype. Levels of mediator-induced Cl secretion in mucous cells were 2-18% those of seromucous cells. Levels of the cystic fibrosis transmembrane conductance regulator (an apical membrane Cl channel) were also much less in mucous than in seromucous cells. These results suggest that serous cells are more important than mucous cells in providing the fluid component of gland secretions.

引用

页码：L206 / L210

页数：5

共 20 条

[1]

ANDERSON MP, 1991, SCIENCE, V253, P203

[2]

BARASCH J, 1993, CYSTIC FIBROSIS CURR, V1, P191

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