SEROTONIN-INDUCED PAW EDEMA IN THE RAT - PHARMACOLOGICAL PROFILE

被引：15

作者：

COLE, HW ^{[1
]}

BROWN, CE ^{[1
]}

MAGEE, DE ^{[1
]}

MAGEE, C ^{[1
]}

ROUDEBUSH, RE ^{[1
]}

BRYANT, HU ^{[1
]}

机构：

[1] ELI LILLY & CO, LILLY CORP CTR, LILLY RES LABS, SKELETAL DIS RES, INDIANAPOLIS, IN 46285 USA

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1995年 / 26卷 / 02期

关键词：

SEROTONIN ANTAGONIST; HISTAMINE ANTAGONIST; DOPAMINE AGONIST; DOPAMINE ANTAGONIST; CALCIUM CHANNEL BLOCKER; IMMUNOSUPPRESSIVE AGENTS; ADRENERGIC AGONIST; ADRENERGIC ANTAGONIST;

D O I：

10.1016/0306-3623(94)00180-U

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Serotonin (5-HT) induced a linear increase in paw weight in rats within 1 hr of an intraplantar injection (50 mu l vol) over a concentration range of 0.005-0.2 mg/ml. At the 0.2 mg/ml concentration, a 16-fold increase in paw weight was observed as compared to saline-injected controls. 2. Serotonin antagonists, such as LY53857, were the most effective antagonists of 5-HT induced paw swelling, producing near complete antagonism and an approximate ED(50) of 0.1 mg/kg. A mixed 5-HT/histamine antagonist, cyproheptadine, also produced a nearly complete inhibition of the 5-HT response with an approximate ED(50) of 1.3 mg/kg. 3. Dopamine agonists (pergolide, quinpirole), yohimbine, dexamethasone and nifedipine also produced a significant degree of antagonism of the 5-HT response. 4. Clonidine, prazocin, chlorpheniramine, cimetidine, various dopamine antagonists, imipramine, cyclosporine A, piroxicam and superoxide dismutase were all ineffective at altering the paw swelling response to 5-HT.

引用

页码：431 / 436

页数：6

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