PREPARATION AND ENHANCING EFFECT OF 1-(N,N-DIMETHYLAMINO)-2-PROPANOL DODECANOATE (DAIPD) ON THE TRANSEPIDERMAL PENETRATION OF CLONIDINE, HYDROCORTISONE, AND INDOMETHACIN THROUGH SHED SNAKE SKIN

1-(N,N-Dimethylamino)-2-propanol dodecanoate (DAIPD), a new biodegradable penetration enhancer was prepared by condensing lauroyl chloride with 1-(N,N-dimethylamino)-2-propanol. The penetration enhancing effects of DAIPD on the transdermal delivery of clonidine, hydrocortisone, and indomethacin were evaluated using shed snake skin (Elaphe obsoleta) as the model membrane. Azone was used as a typical enhancer for comparison. DAIPD showed a 1.2-2-times greater promoting effect than atone for the above-cited drugs. In vitro biodegradability of DAIPD was demonstrated in the presence of porcine esterase. The results indicate that DAIPD increases markedly the transdermal delivery of several types of drug substances.