THE USE OF 1ST-ORDER UV SPECTROSCOPY TO DETERMINE BINARY-MIXTURES OF PHARMACEUTICALS (A) PHEH AND CBOM AND (B) DPHH AND NPZH

被引：20

作者：

SHOUKRALLAH, I

机构：

[1] National Organisation for Druo Control and Research, Cairo

来源：

ANALYTICAL LETTERS | 1991年 / 24卷 / 11期

关键词：

PHENYLEPHRINE HYDROCHLORIDE; CARBINOXAMINE MALEATE; DIPHENHYDRAMINE HYDROCHLORIDE; NAPHAZOLINE HYDROCHLORIDE; DERIVATIVE UV SPECTROPHOTOMETRY; PHARMACEUTICAL FORMS;

D O I：

10.1080/00032719108053032

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Procedures were developed for the simultaneous determination of pharmaceuticals in two-component commercial formulations by first-order derivative UV spectrophotometry. Phenylephrine hydrochloride and carbinoxamine maleate in capsules and diphenhydramine hydrochloride and naphazoline hydrochloride in nasal gelly were successfully assayed. A simple sensitive method in the usual range for the binary preparations has been developed. Average recoveries of the four compounds in the formulations under study were 100.04 + 1.28%, 101.50 +/- 2.27%, 101.59 +/- 1.24% and 100.49 +/- 2.59%.

引用

页码：2043 / 2058

页数：16

共 9 条

[1]

BASILIO M, 1988, J PHARM BIOMED ANAL, V6, P199

[2] APPLICATION OF DERIVATIVE SPECTROSCOPY TO THE DETERMINATION OF PLASMA THEOPHYLLINE IN THE PRESENCE OF PHENOBARBITAL [J].