BASOPHILIC INCLUSIONS IN SPORADIC JUVENILE AMYOTROPHIC-LATERAL-SCLEROSIS - AN IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL-STUDY

被引：41

作者：

MATSUMOTO, S

KUSAKA, H

MURAKAMI, N

HASHIZUME, Y

OKAZAKI, H

HIRANO, A

机构：

[1] MONTEFIORE MED CTR, DEPT PATHOL, DIV NEUROPATHOL, BLUESTONE LAB, BRONX, NY 10467 USA

[2] KITANO HOSP, DEPT NEUROL, OSAKA, JAPAN

[3] NEUROL CTR, OSAKA, JAPAN

[4] HIGASHI NAGOYA NATL HOSP, DEPT NEUROL, NAGOYA, JAPAN

[5] NAGOYA UNIV, SCH MED, DEPT PATHOL 1, NAGOYA, AICHI 466, JAPAN

[6] MAYO CLIN & MAYO GRAD SCH MED, DEPT PATHOL, ROCHESTER, MN 55901 USA

来源：

ACTA NEUROPATHOLOGICA | 1992年 / 83卷 / 06期

关键词：

JUVENILE AMYOTROPHIC LATERAL SCLEROSIS; BASOPHILIC INCLUSION; UBIQUITIN;

D O I：

10.1007/BF00299405

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This report concerns immunocytochemical and ultrastructural studies on the basophilic inclusions in two cases of sporadic juvenile amyotrophic lateral sclerosis (ALS). The inclusion had a globular, irregular-shaped, or sometimes fragmented appearance. Ultrastructurally, the inclusions consisted mainly of thick filamentous structures associated with granules. Focal neurofilamentous accumulations were occasionally observed among the granulofilamentous structures. The basophilic inclusions occasionally showed granular reaction product deposits with an antibody to ubiquitin. The inclusions did not react with antibodies to phosphorylated neurofilament and to tau protein.

引用

页码：579 / 583

页数：5

共 39 条

[1] AN ANTIGENIC PROFILE OF LEWY BODIES - IMMUNOCYTOCHEMICAL INDICATION FOR PROTEIN-PHOSPHORYLATION AND UBIQUITINATION [J].