MATHEMATICAL-MODELING OF REPRODUCTIVE AND DEVELOPMENTAL TOXIC EFFECTS FOR QUANTITATIVE RISK ASSESSMENT

被引：25

作者：

KODELL, RL ^{[1
]}

HOWE, RB ^{[1
]}

CHEN, JJ ^{[1
]}

GAYLOR, DW ^{[1
]}

机构：

[1] CLEMENT INT CORP,RUSTON,LA 71270

来源：

RISK ANALYSIS | 1991年 / 11卷 / 04期

关键词：

LITTER-SIZE; INTRALITTER CORRELATION; THRESHOLD; WEIBULL; RISK ASSESSMENT;

D O I：

10.1111/j.1539-6924.1991.tb00648.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A new mathematical dose-response model for reproductive and developmental risk assessment is proposed. The model includes the possibility of an exposure threshold as well as a litter-size effect. Correlation of responses of offspring from the same litter is taken into account through the use of the beta-binomial distribution. Confidence limits for low-dose extrapolation are based on the asymptotic distribution of the likelihood ratio. An empirical comparison of the proposed procedure to that of Rai and Van Ryzin(1) demonstrates the improvement that can be achieved with the new procedure.

引用

页码：583 / 590

页数：8

共 17 条

[1] QUANTITATIVE RISK ASSESSMENT FOR TERATOLOGICAL EFFECTS [J].