PATHOLOGY OF ATHEROSCLEROSIS IN CHOLESTEROL-FED, SUSCEPTIBLE MICE

被引:32
作者
STEWARTPHILLIPS, JL
LOUGH, J
机构
[1] MCGILL UNIV,DEPT MED,MONTREAL H3A 2T5,QUEBEC,CANADA
[2] MCGILL UNIV,DEPT PATHOL,MONTREAL H3A 2T5,QUEBEC,CANADA
基金
英国医学研究理事会;
关键词
ATHEROSCLEROSIS; PATHOLOGY; LESION; MOUSE;
D O I
10.1016/0021-9150(91)90117-L
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In recent years the C57BL/6J mouse has gained popularity as a model for studying the genetics of diet-induced atherosclerosis. After 10-20 weeks of consuming a diet enriched with saturated fat and cholesterol, it develops fatty streak-like lesions in the valve sinus region of the ascending aorta. The current study shows that continuing the atherogenic diet for a further 15 weeks leads to the development of fibro-fatty lesions which have many of the characteristics of human atheromatous plaques. This finding lends credence to the use of C57BL/6J mice for studying the pathogenesis of atherosclerosis.
引用
收藏
页码:211 / 218
页数:8
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