EXPRESSION OF THE CD11/CD18 CELL-SURFACE ADHESION GLYCOPROTEIN FAMILY ON ALVEOLAR MACROPHAGES IN SMOKERS AND NONSMOKERS

The CD11/CD18 leukocyte surface adhesion glycoprotein family consists of three different heterodimeric molecules that play an essential role in adhesion-related functions such as migration, chemotaxis, and phagocytosis. This suggests an important role of these molecules in inflammatory processes. The three molecules consist of a specific alpha-chain (CD11a, CD11b, or CD11c) and share a common beta-chain (CD18). The expression of the cell adhesion glycoprotein family on alveolar macrophages (AM) and peripheral blood monocytes (PBM) was studied in bronchoalveolar lavage (BAL) fluid samples and PB from 11 smokers and 10 nonsmoking healthy volunteers. Smokers showed increased numbers of macrophages in their BAL fluid as compared with nonsmokers. This is probably due to an increased recruitment of blood monocytes to the alveoli, since the numbers as well as percentages of cells with a monocyte-like morphology were significantly increased in BAL fluid samples from smokers. The proportion of CD11+/CD18+ AM in the BAL fluid from smokers, however, was decreased as compared with AM from nonsmokers and PBM. This suggests that tobacco smoke might play a role in the downregulation of these leukocyte adhesion glycoproteins on AM.